Notably, health care-associated infections (HAIs) caused by S. aureus clones have been reported in health care institutions in Ghana with the sequence types (ST) 15, 121 and 152 being the most prevalent as determined by multi-locus sequence typing (MLST). aureus isolated from the wounds of BU and EB patients has shown that their wounds often harbor multiple genotypes of this pathogen.
PBP3 PNEUMONIAE TRIM SKIN
aureus colonization of patients with a serious breach of skin barrier, such as patients with BU, burn wounds or the group of hereditary mechanobullous diseases epidermolysis bullosa (EB), was previously shown to be very high. aureus infections that are difficult to treat. aureus is regarded as a risk factor for future development of S.
Colonization of healthy individuals with multi-drug resistant S.
aureus is considered a dangerous pathogen in both community-acquired and nosocomial infections. However, once it crosses the skin barrier, or when the host immune system is compromised, this bacterium is able to cause a wide range of diseases, such as skin and soft tissue infections, osteomyelitis, pneumonia, meningitis, or bacteremia. aureus can be part of the human microbiota colonizing the skin and mucosal membranes without any clinical manifestations. It was previously shown that wounds of most BU patients are heavily colonized by many microorganisms, including Staphylococcus aureus. The disease usually starts as a nodule, plaque, oedema or papule and progresses to form large ulcers with undermined edges if left untreated. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.īuruli ulcer (BU) is a neglected necrotizing skin disease caused by Mycobacterium ulcerans, with the highest burden of the disease in West Africa, particularly in Benin, Cote d’Ivoire and Ghana. YS was supported by a VENI grant from the Netherlands Organisation for Scientific Research and the Gratama foundation. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper and its Supporting Information file.įunding: NAA was supported by fellowships from the Graduate School for Medical Sciences of the University of Groningen.
Received: Accepted: AugPublished: September 11, 2015Ĭopyright: © 2015 Amissah et al. Small, University of Tennessee, UNITED STATES PLoS Negl Trop Dis 9(9):Įditor: Pamela L. (2015) Molecular Characterization of Staphylococcus aureus Isolates Transmitted between Patients with Buruli Ulcer. Citation: Amissah NA, Chlebowicz MA, Ablordey A, Sabat AJ, Tetteh CS, Prah I, et al.